Changes And Development Of The Aging Process - 1972 Words

Epigenetic changes are currently recognized as part of the aging process and have been implicated in many age-related chronic diseases such as AD (1–3). The term epigenetics includes a variety of processes known to regulate gene expression in a stable and potentially reversible way, without altering the primary DNA sequence (4). Since epigenetics allow for the integration of long-lasting non-genetic inputs in the genome, research on age-related disorders have recently focused in epigenetic mechanisms, and a growing number of epigenetic alterations in AD have been described recently (5). The best characterized epigenetic mechanisms include DNA methylation, histone posttranslational modifications, and non-coding RNAs such as microRNAs (miRNAs). It is becoming increasingly evident the interplay between these mechanisms to establish the epigenetic states and expression patterns of many mammalian genes (1–3). For instance, it has been described that trimethyla tion of histone 3 at lysine 9 (H3K9me3) by the histone methyl transferase SUV39H1 is required for recruiting the DNA methyl transferase DNMT3b to pericentromeric repeats in order to allow heterochromatin structure (both H3-K9 methylation and DNA methylation are considered hallmarks of mammalian heterochromatin) (4). In turn, miRNAs can also control other epigenetic mechanisms; for example, miR-204 can target histone deacetylase 4 (HDAC4) (5), while miR-148 and miR-152 are reported to influence DNA methylationShow MoreRelatedAging Is A Process Of A Disease Based On Genetic Makeup ( Schneider )1206 Words   |  5 PagesAging is a process through which organism’s functionality decline systematically. The decrease in human organism is due to genetic cellular and molecular modifications. The level of changes on the longevity of the plant can affect it in several ways in a gradual process as the age progresses with time. 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International Construction Floor Packaging Method

Question: Discuss about theInternational Constructionfor Floor Packaging Method. Answer: Introduction Ashori, Tabarsa, and Sepahvand, (2011) says that the level packaging methods refer to the manufacturing and packaging processes of, and the devices used thereby together with the floor panels and the already prepared packages of the floor boards. The methods refer to the solid panels which make the levels which are usually two-sided or more. These partitions come provided with coupling parts which can be availed on a floating or glued subfloor (Ashori, Tabarsa, and Sepahvand, 2011). Either style is used to act as a floor covering. At this moment, the intention for the invention particularly for the laminate panels, for example, has a printed dcor and a top structure as a base for the synthetic fiber (Ashori, Tabarsa, and Sepahvand, 2011). There are also prefabricated parquets, with panels which consist mostly of groups having layers of veneer on the upper side or the or the solid flooring. This style does not finalize that the invention is not applicable to some other hard floor panels. The hard floor panels can be composed of several layers or just a single one with the layers comprising of either coke, carpet or stone-like materials. Benefits of the Floor Packaging Methods. Romero et al., (2015) and Peurifoy and Oberlender, (n.d.) makes an acknowledgment that topping the list of the benefits gained due to the application of the intervention is the great reduction in the expense of building the floor by almost a third of the overall cost. Secondly, according to (Romero et al., 2015), because the panels act as the floor. Therefore the required thickness of the floor is significantly reduced. Thirdly and also just as important is the great reduction in wastage of unusable cut off parts. These parts get recycled to make more compact and full panels which are made up of 95% recycled waste parts. Constructors also get to benefit from the reduction in building time as there is no stoppage in the construction process by waiting for the floors to dry as it was with the traditional structures (Li et al., 2014; Romero et al., 2015). Applicability in India and Australia Most of the modern day developments in Australia incorporates the use of the floor packaging methods more so because of the high levels of technology in the country. India is also another country where the application of floor packaging is quickly getting appreciated (Allen and Ian, n.d.). In both countries depending on the level of technological prowess, certain new constructions like airports, warehouse floors, educational institutions, hospitals and also offices as do adorn instances of the methods (Allen and Iano, n.d.). The application and use of these floor structures have led to the development of floor packaging industries like the fast growing Flowcrete in India (Lawson et al., 2015). This firm deals with all the requirements regarding the level packaging methods. With an official policy which commands it a place as the global leader in seamless flooring, this enterprise specializes in almost all the floor requirements (Allen and Iano, n.d.; Choi et al., 2015). Some of the areas they prosper in include floor screeds which level themselves (Hiramitsu, 2012), underfloor heating (Kuratomi and Inada, 2015). They also feature in industrial flooring in addition to waterproofing systems of the car pack deck (Lam et al., 2015). The company maintains a global presence by having facilities in countries like Belgium, Australia, Sweden, the United Kingdom Malaysia, and Brazil. Case Study of Floor Packaging Neeli Aqua India Pvt. Ltd Flowcrete India has been collaborating with Neeli Aqua India Pvt. Ltd to develop a high performing floor by incorporating samples of the floor packaging at the firm. This collaboration was only achievable by having an antimicrobial flooring solution which maintains an effective floor finishing despite the constant traffic. The buildings floor had an incorporation of the water based Flowfresh Primer floor packaging that is not easily destroyed by water or other liquids. As a food processing plant, the building used Flowtex F1 Coving Mortar that withstands the cold extreme cold temperatures which can reach up to -50 degrees centigrade. Deckshield Advantage Technological advances in the floor packaging today has enabled constructional developers to choose eco-friendly methods of construction which not only provide high-quality end products but also make enhancements on a sites green capabilities. Moreover, a rise in the development complexities and due to evolution and growth of multipurpose buildings has brought in the need for installing a variety of floor finishings to match particular requirements. This condition leads to the need for outsourcing of different quality material suppliers. It is a matter of consideration to check the durability of the materials, the probable expense, and the eco-friendliness before settling on a provider. Abu Dhabi National Oil Company (ADNOC) did want to create a parking compartment with a sustainable ethos. Therefore, it chooses a solution that did ensure the installation of a durable floor coupled up with eco-friendly capabilities. The Deckshield ES car pack coating system from Indias Flowcrete was the most suitable due to its ability to present a visually pleasant finish which is durable despite the physical challenges it endures. Thereby it assists in preventing the need for a frequent refurbishment. The resin within the floors material is designed in such a way that upon growing old, preparation systems can be applied to restore the surface to new form. This technology is conversant with many types of floors including asphalt, wood or metal whereby the resin system gets used right on top of the old surface. The Deckshield ES design favors the environment-friendly capabilities through its car-pooling service. The floor packaging has visible designs that make the identification of the carpooling spaces comfortable. This visibility is achievable by having bright colorings on the floor marking the parking space. Therefore, the overall vehicle emissions get reduced substantially earning the building the admirable LEED credits. The buildings constructors made cost analysis to help the facility operators and owners to effectively make long-term budgets while at the same time identifying materials like those from the Flowcrete range of products. The application and use of these high standard materials helped the ADNOC owners to avoid initial environmental costs through refurbishments. Bibliography Allen, E. and Iano, J. (n.d.). Fundamentals of building construction. Ashori, A., Tabarsa, T. and Sepahvand, S. (2011). Cement-bonded composite boards made from poplar strands. Construction and Building Materials. Choi, S., Kudoh, R., Koga, J., Mikami, T., Yokoyama, Y., Takahashi, H., and Ono, H. (2015). A comparative evaluation of floor slips resistance test methods. Construction and Building Materials, 94, pp.737-745. Hiramitsu, A. (2012). Effect of floating floor and raised the level on floor impact sound insulation of wooden construction. The Journal of the Acoustical Society of America, 131(4), pp.3320-3320. Kuratomi, Y. and Inada, T. (2015). Development of the structural system with a steel frame and wooden floor -Connection method of steel beam and wooden floors. IABSE Symposium Report, 105(12), pp.1-8. Lam, D., Dai, X., Kuhlmann, U., Raichle, J. and Braun, M. (2015). Slim-floor construction - design for the ultimate limit state. Steel Construction, 8(2), pp.79-84. Lawson, M., Beguin, P., Obiala, R. and Braun, M. (2015). Slim-floor construction using hollow-core and composite decking systems. Steel Construction, 8(2), pp.85-89. Li, Q., Chen, C., Zhang, Y., Lin, J. and Ling, H. (2014). The simplified thermal calculation method for floor structure in radiant floor cooling system. Energy and Buildings, 74, pp.182-190. Peurifoy, R. and Oberlender, G. (n.d.). Estimating construction costs. Romero, M., Cajot, L., Conan, Y. and Braun, M. (2015). Fire design methods for slim-floor structures. Steel Construction, 8(2), pp.102-109.